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Wagistrasse 12, Schlieren

publications 2019-10-04T12:03:52+00:00


  • Oppi S, Nusser-Stein S, Blyszczuk P, Wang X, Jomard A, Marzolla V, Yang K, Velagapudi S, Ward LJ, Yuan XM, Geiger MA, Guillaumon AT, Othman A, Hornemann T, Rancic Z, Ryu D, Oosterveer MH, Osto E, Luscher TF, Stein S. (2019) Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARgamma signature. Eur Heart J. 2019 Sep 16. pii: ehz667. doi: 10.1093/eurheartj/ehz667
  • Williams EG, Stein S. (2019). JCAD: from systems genetics identification to the experimental validation of a coronary artery disease risk locus. Eur Heart J 40, 2409-2412.
  • Oppi S, Luscher TF, Stein S. (2019). Mouse Models for Atherosclerosis Research-Which Is My Line? Front Cardiovasc Med 6, 46.
  • Geiger M, Stein S. (2018) Adipose tissue macrophage polarization in cardiovascular disease. Eur J Prev Cardiol 25, 325-327.
  • Stein S, Matter CM. (2017) Protective role of the co-stimulator CD27 receptor and regulatory T cells in early atherogenesis. Eur Heart J. 38, 3600-3602.
  • Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O’Reilly LA, Stoffel M, Auwerx J, Konrad D. (2017) Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.  Nat Commun 8(1):480.
  • Stein, S., Lemos, V., Xu, P., Demagny, H., Wang, X., Ryu, D., Jimenez, V., Bosch, F., Lüscher, T.F., Oosterveer, M.H., Schoonjans, K. (2017) Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest 127:583-592.
  • Gariani, K., Ryu, D,, Menzies, K.J., Yi, H.S., Stein, S., Zhang, H., Perino, A., Lemos, V., Katsyuba, E., Jha, P., Vijgen, S., Rubbia-Brandt, L., Kim, Y.K., Kim, J.T., Kim, K.S., Shong, M., Schoonjans, K., Auwerx, J. (2017) Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. J Hepatol 66:132-141.
  • Stein, S., Winnik, S., and Matter, C.M. (2017). Brain-derived neurotrophic factor Val66Met polymorphism in depression and thrombosis: SIRT1 as a possible mediator. Eur Heart J 38, 1436-1438.
  • Xu, P., Oosterveer, M.H., Stein, S., Demagny, H., Ryu, D., Moullan, N., Wang, X., Can, E., Zamboni, N., Comment, A., Auwerx, J., and Schoonjans, K. (2016). LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer. Genes Dev 30, 1255-1260.
  • Stein S, Matter CM. (2016). CardioPulse: Translational research in cardiovascular disease. Eur Heart J 37, 1088-1095.
  • Stein, S., and Schoonjans, K. (2015). Molecular basis for the regulation of the nuclear receptor LRH-1. Curr Opin Cell Biol 33, 26-34.
  • Lefevre, L., Authier, H., Stein, S., Majorel, C., Couderc, B., Dardenne, C., Eddine, M.A., Meunier, E., Bernad, J., Valentin, A., Pipy, B., Schoonjans, K., and Coste, A. (2015). LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARgamma ligand synthesis. Nat Commun 6, 6801.
  • Miranda, M.X., van Tits, L.J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A.P., Suri, V., Ellis, J.L., Lutz, T.A., Hottiger, M.O., Sinclair, D.A., Auwerx, J., Schoonjans, K., Staels, B., Luscher, T.F., and Matter, C.M. (2015). The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. Eur Heart J 36, 51-59.
  • Stein, S., and Schoonjans, K. (2015). Targeting SUMOylation of LRH-1 to Combat Atherosclerosis. International Atherosclerosis Society.
  • Ryu, D., Jo, Y.S., Lo Sasso, G., Stein, S., Zhang, H., Perino, A., Lee, J.U., Zeviani, M., Romand, R., Hottiger, M.O., Schoonjans, K., and Auwerx, J. (2014). A SIRT7-Dependent Acetylation Switch of GABPbeta1 Controls Mitochondrial Function. Cell Metab 20, 856-869.
  • Akhmedov, A., Rozenberg, I., Paneni, F., Camici, G.G., Shi, Y., Doerries, C., Sledzinska, A., Mocharla, P., Breitenstein, A., Lohmann, C., Stein, S., von Lukowicz, T., Kurrer, M.O., Boren, J., Becher, B., Tanner, F.C., Landmesser, U., Matter, C.M., and Luscher, T.F. (2014). Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo. Eur Heart J 35, 2839-2848.
  • Stein, S., Oosterveer, M.H., Mataki, C., Xu, P., Lemos, V., Havinga, R., Dittner, C., Ryu, D., Menzies, K.J., Wang, X., Perino, A., Houten, S.M., Melchior, F., and Schoonjans, K. (2014). SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport. Cell Metab 20, 603-613.
  • Perino, A., Pols, T.W., Nomura, M., Stein, S., Pellicciari, R., and Schoonjans, K. (2014). TGR5 reduces macrophage migration through mTOR-induced C/EBPbeta differential translation. J Clin Invest 124, 5424-5436.
    Winnik, S., Stein, S., and Matter, C.M. (2012). SIRT1 – An Anti-Inflammatory Pathway at the Crossroads Between Metabolic Disease and Atherosclerosis. Curr Vasc Pharmacol 10, 693-696.
  • Besler, C., Heinrich, K., Rohrer, L., Doerries, C., Riwanto, M., Shih, D.M., Chroni, A., Yonekawa, K., Stein, S., Schaefer, N., Mueller, M., Akhmedov, A., Daniil, G., Manes, C., Templin, C., Wyss, C., Maier, W., Tanner, F.C., Matter, C.M., Corti, R., Furlong, C., Lusis, A.J., von Eckardstein, A., Fogelman, A.M., Luscher, T.F., and Landmesser, U. (2011). Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest 121, 2693-2708.
  • Stein, S., and Matter, C.M. (2011). Protective roles of SIRT1 in atherosclerosis. Cell Cycle 10, 640-647.
  • Breitenstein, A., Stein, S., Holy, E.W., Camici, G.G., Lohmann, C., Akhmedov, A., Spescha, R., Elliott, P.J., Westphal, C.H., Matter, C.M., Luscher, T.F., and Tanner, F.C. (2011). Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res 89, 464-472.
  • Blyszczuk, P., Germano, D., Stein, S., Moch, H., Matter, C.M., Beck-Schimmer, B., Luscher, T.F., Eriksson, U., and Kania, G. (2011). Profibrotic potential of prominin-1(+) epithelial progenitor cells in pulmonary fibrosis. Respir Res 12, 126.
  • Rajapakse, A.G., Yepuri, G., Carvas, J.M., Stein, S., Matter, C.M., Scerri, I., Ruffieux, J., Montani, J.P., Ming, X.F., and Yang, Z. (2011). Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol. Plos One 6, e19237.
  • Stein, S., Lohmann, C., Schafer, N., Hofmann, J., Rohrer, L., Besler, C., Rothgiesser, K.M., Becher, B., Hottiger, M.O., Boren, J., McBurney, M.W., Landmesser, U., Luscher, T.F., and Matter, C.M. (2010a). SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis. Eur Heart J 31, 2301-2309.
  • Stein, S., Schafer, N., Breitenstein, A., Besler, C., Winnik, S., Lohmann, C., Heinrich, K., Brokopp, C.E., Handschin, C., Landmesser, U., Tanner, F.C., Luscher, T.F., and Matter, C.M. (2010b). SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging (Albany NY) 2, 353-360.
  • Stein, S., Lohmann, C., Handschin, C., Stenfeldt, E., Boren, J., Luscher, T.F., and Matter, C.M. (2010c). ApoE-/- PGC-1alpha-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. Plos One 5, e13539.
  • Stobe, P., Stein, S.M.A., Habring-Muller, A., Bezdan, D., Fuchs, A.L., Hueber, S.D., Wu, H., and Lohmann, I. (2009). Multifactorial regulation of a hox target gene. PLoS Genet 5, e1000412.
  • Zhai, Z., Stein, M.A., and Lohmann, I. (2009). Expression of the apoptosis gene reaper in homeotic, segmentation and other mutants in Drosophila. Gene Expr Patterns 9, 357-363.
  • Lohmann, C., Schafer, N., von Lukowicz, T., Sokrates Stein, M.A., Boren, J., Rutti, S., Wahli, W., Donath, M.Y., Luscher, T.F., and Matter, C.M. (2009). Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets. Atherosclerosis 207, 360-367.
  • Kania, G., Blyszczuk, P., Stein, S., Valaperti, A., Germano, D., Dirnhofer, S., Hunziker, L., Matter, C.M., and Eriksson, U. (2009). Heart-infiltrating prominin-1+/CD133+ progenitor cells represent the cellular source of transforming growth factor beta-mediated cardiac fibrosis in experimental autoimmune myocarditis. Circ Res 105, 462-470.
  • Matter, C.M., and Stein, M.A. (2009). A dual role of CD4+ T cells in adipose tissue? Circ Res 104, 928-930.