Atherosclerosis is a chronic inflammatory disease that evolves during decades in humans and remains asymptomatic until an atherosclerotic plaque may rupture and cause a myocardial infarction or stroke. The disease is characterized by a complex interaction of vascular and immune cells, different tissues and organs, and triggered by hypercholesterolemia and other risk factors. We are studying different transcriptional regulators and their effects on atherosclerosis development and progression, given special focus to important transcriptional coregulators, such as SIRT1 and PROX1. These cofactors play an important role in the regulation of gene expression under physiological and pathological conditions. Given the fact that myocardial infarction and stroke remain two of the primary causes of mortality in the world, there is a clear biomedical interest to identify and understand new (anti) atherogenic pathways. In collaboration with the clinical groups we are also validating our basic research findings in human samples from patients suffering from cardiovascular disease.
research Sokrates Stein 2017-05-19T09:40:29+00:00